type i interferons การใช้

• Laboratory mice deficient in type I interferon response are resistant to experimental cerebral malaria.
• After TBK1's activity to phosphorylate IRF3 and STAT6 for downstream type I interferon response.
• This gene encodes a cytokine distantly related to type I interferons and the IL-10 family.
• In addition to its role during DNA replication, POLA1 plays a role in type I interferon activation.
• High type I interferon signature leads to the " M . tuberculosis " pathogenesis and prolonged infection.
• Dr . Portnoy and Dr . Russell Vance identified that type I interferon and other co-regulated genes.
• This work was based on experiments in mice that suggested that type I interferons could enhance the effectiveness of influenza vaccines in mice.
• IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including the type I interferon genes.
• Activation of these receptor leads to production of inflammatory cytokines as well as type I interferons ( interferon type I ) to help fighting viral infection.
• JAK1 and JAK2 are involved in type II interferon ( interferon-gamma ) signalling, whereas JAK1 and TYK2 are involved in type I interferon signalling.
• STING mediates the Type I interferon produced by infected cells can find and bind to Interferon-alpha / beta receptor of nearby cells to protect cells from local infection.
• STING-TBK1-IRF mediated type I interferon response is central to the pathogenesis of experimental cerebral malaria in laboratory animals infected with " Plasmodium berghei ".
• Type I interferons ( IFN ), secreted mainly by dendritic cells, play the central role in antiviral host defense and creation of an effective antiviral state in a cell.
• Recent work has suggested that the type I interferon response ( specifically that of interferon alpha and beta ) is an important factor that defines which types of cells support poliovirus replication.
• IFN? is the only Type II interferon and it is serologically distinct from Type I interferons; it is acid-labile, while the type I variants are acid-stable.
• A series of publications from the laboratories of Sidney Pestka and Alan Waldman between 1978 and 1981, describe the purification of the type I interferons IFN-? and IFN-?.
• Type I interferon activity was originally described over 50 years ago as a soluble factor produced by cells treated with inactivated, non-replicating viruses that blocked subsequent infection with live virus.
• The reduction in POLA1 expression is accompanied by marked reduction in cytosolic RNA : DNA hybrid molecules and a concomitant hyperactivation of the IRF pathway, with consequent overproduction of type I interferons.
• The IL-26 DNA complexes triggered the production of type I interferon by plasmacytoid dendritic cells via activation of Toll-like receptor 9, but independently of the IL-26 receptor.
• From 1984 to 2003 Stewart was a scientist at Genentech where he developed the concept that the type I interferons might be a significant component in the initiation or progression of type I diabetes.